This course will expand upon concepts introduced in pathophysiology and previous systems-based courses. Students will learn to address multiple disease pathologies and co-morbidities as they compound to produce medically complex situations. The learner will examine implications for the physical therapist management of the medically complex person across the continuum of care including inpatient, outpatient, home-based, and institutional settings. This course will take a problem-based learning approach which will include the musculoskeletal, nervous, cardiovascular, pulmonary, metabolic, gastrointestinal, hepatic, renal, lymphatic, immune, reproductive, and integumentary systems as well as disorders related to infectious disease, substance abuse, immunodeficiencies, oncology, and surgical procedures.